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Anti Diabetic Property of Aqueous Extract of Stevia Rebaudiana Bertoni Leaves in Streptozotocin-induced Diabetes in Albino Rats

Anti Diabetic Property of Aqueous Extract of Stevia Rebaudiana Bertoni Leaves in Streptozotocin-induced Diabetes in Albino Rats

Uswa Ahmad, Rabia Shabir Ahmad

BMC Complement Altern Med. 2018 Jun 11;18(1):179.

PMID: 29890969

Abstract:

Background:
Stevia (Stevia rebaudiana) natural, non-caloric sugar substitute is rich source of pharmacologically important glycoside stevioside that is linked to the pathology and complications of diabetes.
Methods:
The current research was carried out to explore the anti-diabetic effect of aqueous extract of Stevia rebaudiana leaves in albino rats. For this purpose, diabetes was induced by administration of streptozotocin (40 mg/kg body weight, intraperitoneally). The diabetic rats were administered with aqueous stevia extract at different dose levels (200, 300, 400 and 500 ppm/kg b.w) for 8 weeks; the control rats were fed basal diet during this period.
Results:
Stevia aqueous extract improved caloric management and weight control by decreasing the feed intake and body weight gain. Furthermore, intake of stevia extract resulted in significant (P < 0.05) decrease in the random blood glucose level (- 73.24%) and fasting blood glucose (- 66.09%) and glycosylated (HbA1c) hemoglobin (5.32%) while insulin (17.82 μIU/mL) and liver glycogen (45.02 mg/g) levels significantly improved in the diabetic rats, compared with the diabetic and non-diabetic control rats after 8 weeks study period.
Conclusions:
It is concluded that aqueous extact of stevia has anti-diabetic effects in albino rats, and therefore could be promising nutraceutical therapy for the management of diabetes and its associated complications.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP91722213-A	Stevia extract		91722-21-3	Price

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