Home
Resources
Publications
Anti-inflammatory Activity of Hydrosols From Tetragonia Tetragonoides in LPS-induced RAW 264.7 Cells

Anti-inflammatory Activity of Hydrosols From Tetragonia Tetragonoides in LPS-induced RAW 264.7 Cells

Eun-Yi Ko, Su-Hyeon Cho, Kyungpil Kang, Gibeom Kim, Ji-Hyeok Lee, You-Jin Jeon, Daekyung Kim, Ginnae Ahn, Kil-Nam Kim

EXCLI J. 2017 Apr 18;16:521-530.

PMID: 28694755

Abstract:

The present study was performed to investigate the anti-inflammatory activity of Tetragonia tetragonoides hydrosols (TTH) and its underlying mechanism in lipopolysaccharide (LPS)-induced RAW 264.7 cells. Gas chromatography (GC) coupled with mass spectrometry and retention index calculations showed that TTH were mainly composed of tetratetracontane (29.5 %), nonacosane (27.6 %), and oleamide (17.1 %). TTH significantly decreased the production of nitric oxide (NO), prostaglandin E2 (PGE2), interleukin (IL)-6, and IL-1β in LPS-stimulated RAW 264.7 cells. Consistent with these observations, TTH treatment decreased the protein expression levels of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2). The molecular mechanism of its anti-inflammatory activity was found to be associated with inhibition of nuclear factor-kappa B (NF-κB) phosphorylation and nuclear translocation of NF-κB 65. Furthermore, TTH markedly suppressed the LPS-induced phosphorylation of mitogen-activated protein kinases (MAPKs). Taken together, these data indicate that TTH exerts an anti-inflammatory activity by inhibiting the NF-κB and MAPK signaling pathways in LPS-stimulated RAW 264.7 cells.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP7098228	Tetratetracontane		7098-22-8	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: