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Anti-inflammatory Activity of Rolipram in a Rat Ear Edema Model

Anti-inflammatory Activity of Rolipram in a Rat Ear Edema Model

W Krause, G Kühne

Arzneimittelforschung. 1994 Feb;44(2):163-5.

PMID: 8147951

Abstract:

In the present study the anti-inflammatory activity of the phosphodiesterase inhibitor rolipram (ZK 62,711, CAS 61413-54-5) was tested in a rat model where edema was induced in the ears of the animals by the epicutaneous application of croton oil in ethanol (5%, by volume). The administration of 0.015, 0.15 and 1.5 mg rolipram per ear dose-dependently inhibited the formation of edema. Concomitantly, the body temperature of the rats was decreased. 4-14% of rolipram was percutaneously absorbed within a 5-h interval. The absorbed proportion, represented by the area under the plasma level-time curve, correlated with the inhibition of edema formation and with the decrease in body temperature.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP61413545-B	Rolipram - CAS 61413-54-5		61413-54-5	Price

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