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Anti-inflammatory Constituents From Psychotria Prainii H. Lév

Anti-inflammatory Constituents From Psychotria Prainii H. Lév

Phi Hung Tran, Viet Dung Le, Thi Ha Do, Thi Luyen Nguyen, Phuong Thao Nguyen, Trong Thong Nguyen, Tien Dat Nguyen

Nat Prod Res. 2019 Mar;33(5):695-700.

PMID: 29212359

Abstract:

One new and three known compounds were isolated from the ethanol extract of Psychotria prainii aerial parts. By means of spectroscopic methods, their structures were elucidated to be deacetylasperulosidic acid 6-ethyl ether (1), asperulosidic acid (2), asperuloside (3) and obtucarbamates C (4). The isolated compounds were evaluated for their inhibitory effect on NO production in LPS-stimulated RAW264.7 cells. Among them, compounds 2 and 4 exhibited strong effect with the IC50 values of 5.75 ± 0.85 and 6.92 ± 0.43 μM, respectively. This is the first report for the chemical composition and biological activity of P. prainii.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP14259553	Deacetylasperulosidic acid		14259-55-3	Price

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