Home
Resources
Publications
Anti-inflammatory Effects of β-sitosterol-β-D-glucoside From Trachelospermum Jasminoides (Apocynaceae) in Lipopolysaccharide-Stimulated RAW 264.7 Murine Macrophages

Anti-inflammatory Effects of β-sitosterol-β-D-glucoside From Trachelospermum Jasminoides (Apocynaceae) in Lipopolysaccharide-Stimulated RAW 264.7 Murine Macrophages

Ji Na Choi, Yun-Hyeok Choi, Jeong-Min Lee, Ill Chan Noh, Jae Won Park, Wahn Soo Choi, Jung Ho Choi

Nat Prod Res. 2012;26(24):2340-3.

PMID: 22292934

Abstract:

Trachelospermum jasminoides (Apocynaceae) has pharmacological effects that include anti-inflammatory, anti-bacterial and anti-viral activities, which have been observed from various studies. Of these pharmacological effects, the anti-inflammatory capacity of compounds from T. jasminoides is not yet known exactly. In this study, we investigated the compound that can be used for the suppression of lipopolysacchaide (LPS) stimulated inflammatory responses in macrophages among the five isolated compounds. β-sitosterol-β-D-glucoside (1) was found to reduce nitric oxide (NO) production from LPS-induced RAW 264.7 cells the most. In addition, compound 1 strongly inhibited the interleukin 6 (IL-6) activities of stimulated macrophages. Treatment of RAW 264.7 cells with compound 1 reduced secretion of inflammatory elements including tumour necrosis factor - alpha (TNF-α) and interleukin 1 beta (IL-1β). Thus, compound 1 may be a useful candidate for the development of new drugs to treat endotoxemia and inflammation accompanied by the overproduction of NO.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP474588	β-Sitosterol β-D-glucoside		474-58-8	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: