Home
Resources
Publications
Anti-neuroblastoma Activity of Helminthosporium Carbonum (HC)-toxin Is Superior to That of Other Differentiating Compounds in Vitro

Anti-neuroblastoma Activity of Helminthosporium Carbonum (HC)-toxin Is Superior to That of Other Differentiating Compounds in Vitro

Hedwig E Deubzer, Volker Ehemann, Andreas E Kulozik, Frank Westermann, Larissa Savelyeva, Annette Kopp-Schneider, Daniel Riester, Manfred Schwab, Olaf Witt

Cancer Lett. 2008 Jun 8;264(1):21-8.

PMID: 18262346

Abstract:

Treatment of high-risk neuroblastoma (NB) is difficult. Novel therapeutics improving survival rates are urgently required. We have previously shown that the histone deacetylase inhibitor (HDACI) Helminthosporium carbonum (HC)-toxin induces differentiation of neuroblastoma (NB) cells. Here, we show that HC-toxin inhibits the growth of both established NB cell lines and primary cultures with and without amplified MYCN stronger than retinoids (RAs) and other HDACIs (MS-275, n-butyric acid, suberoylanilide hydroxamic acid, trichostatin A, valproic acid). Nanomolar dosages suppress E2F-1, N-myc, Skp2, Mad2 and survivin proteins, found at high levels in high-risk NBs, more efficiently than both RAs and other HDACIs. The level of hypophosphorylated active retinoblastoma (RB) tumor suppressor protein is increased most effectively. HC-toxin's epoxy group is essential for inhibiting HDACs and promoting anti-NB activity. Without this functional group, those cellular effects are not observed. In conclusion, the anti-NB activity of HC-toxin is superior to that of RAs and that of all other HDACIs tested.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP83209658	HC toxin from Helminthosporium carbonum		83209-65-8	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: