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Anti-neutrophilic Inflammatory Steroidal Glycosides From Solanum Torvum

Chia-Lin Lee, Tsong-Long Hwang, Wan-Jung He, Yi-Hong Tsai, Chiao-Ting Yen, Hsin-Fu Yen, Chao-Jung Chen, Wei-Yi Chang, Yang-Chang Wu

Phytochemistry. 2013 Nov;95:315-21.

PMID: 23838628

Abstract:

Torvpregnanosides A and B, two pregnane glycosides, and torvoside Q, a 23-keto-spirostanol glycoside, along with twelve known steroidal saponins were isolated from aerial parts of Solanum torvum. Of the latter, four of the 23-hydroxy-spirostanol glycosides, and, a yamogenin glycoside, were in this plant discovered. All structures were identified from spectroscopic data, and all the compounds were tested for in vitro anti-neutrophilic inflammatory activity. Two compounds showed selective inhibition against elastase release and superoxide anion generation, respectively, by human neutrophils with IC50 values of 5.66 and 3.59 μM, while two others inhibited both inflammatory mediators with IC50 values of 0.66-3.49 μM. Structure-activity relationships are discussed.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP512061 Yamogenin Yamogenin 512-06-1 Price
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