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Antiasthmatic Effects of Schizandrae Fructus Extract in Mice With Asthma

Antiasthmatic Effects of Schizandrae Fructus Extract in Mice With Asthma

Hyungwoo Kim, Yong-Tae Ahn, Youn Sook Kim, Su In Cho, Won Gun An

Pharmacogn Mag. 2014 Jan;10(Suppl 1):S80-5.

PMID: 24914313

Abstract:

Background:
Schizandrae fructus (SF), the fruit of Schisandra chinensis, has been used for the treatment of cough, wheezing, dry mouth, hepatitis, cardiovascular disease, and as a tonic and astringent in China, Japan, and Korea.
Objective:
Investigation of the antiasthmatic effects of SF.
Materials and methods:
We investigated the effects of SF on airway hyperresponsiveness (AHR) to methacholine, production levels of antigen-specific antibodies, and histopathological changes in the lung tissue in a mouse model (Balb/c) of asthma induced by repeated intranasal instillation of an antigen.
Results:
SF lowered AHR to methacholine (P < 0.05), antigen-specific immunoglobulin E (IgE) level (P < 0.01), and immune cell infiltration in mice with asthma. Prednisolone (PD) effectively decreased AHR (P < 0.01), total antibody (P < 0.01) and IgE (P < 0.01) levels, and immune cell infiltration. SF and PD did not affect the levels of antigen-specific IgG1 and IgG2a antibodies.
Conclusion:
Our data suggest that SF has possible application as an antiasthmatic drug. We also suggest that SF could be used as a complementary or alternative medicine to glucocorticoids.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
CS31043121	Schisandra chinensis Fruit Dry Extract			Price

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