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Antibacterial Activity of Extracts and Constituents of Pelargonium Sidoides and Pelargonium Reniforme

Antibacterial Activity of Extracts and Constituents of Pelargonium Sidoides and Pelargonium Reniforme

O Kayser, H Kolodziej

Planta Med. 1997 Dec;63(6):508-10.

PMID: 9434601

Abstract:

The antibacterial activity of extracts and isolated constituents (scopoletin, umckalin, 5,6,7-trimethoxycoumarin, 6,8-dihydroxy-5,7-dimethoxycoumarin, (+)-catechin, gallic acid and its methyl ester) of Pelargonium sidoides and Pelargonium reniforme (Geraniaceae), plant species used in folk medicine by the Southern African native population, was evaluated against 8 microorganisms, including 3 Gram-positive (Staphylococcus aureus, Streptococcus pneumoniae, and beta-hemolytic Streptococcus 1451) and 5 Gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Haemophilus influenzae). Minimum inhibitory concentrations (MICs) varied with the preparation of the extracts and microorganisms tested, from about 0.6 mg/ml for aqueous phases to over 10 mg/ml for crude Pelargonium extracts. With the exception of the ineffective (+)-catechin, all the potentially active compounds exhibited antibacterial activities with MICs of 200-1000 micrograms/ml. The results provide for a rational basis of the traditional use of the titled Pelargonium species.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP43053629	Umckalin		43053-62-9	Price

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