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Antibacterial Adhesion of Poly(methyl Methacrylate) Modified by Borneol Acrylate

Antibacterial Adhesion of Poly(methyl Methacrylate) Modified by Borneol Acrylate

Xueli Sun, Zhiyong Qian, Lingqiong Luo, Qipeng Yuan, Ximin Guo, Lei Tao, Yen Wei, Xing Wang

ACS Appl Mater Interfaces. 2016 Oct 26;8(42):28522-28528.

PMID: 27712052

Abstract:

Poly(methyl methacrylate) (PMMA) is a widely used biomaterial. But there is still a challenge facing its unwanted bacterial adhesion because the subsequent biofilm formation usually leads to failure of related implants. Herein, we present a borneol-modified PMMA based on a facile and effective stereochemical strategy, generating antibacterial copolymer named as P(MMA-co-BA). It was synthesized by free radical polymerization and studied with different ratio between methyl methacrylate (MMA) and borneol acrylate (BA) monomers. NMR, GPC, and EA, etc., were used to confirm their chemical features. Their films were challenged with Escherichia coli (Gram-negative) and Bacillus subtilis (Gram-positive), showing a BA content dependent antibacterial performance. The minimum effective dose should be 10%. Then in vivo subcutaneous implantations in mice demonstrated their biocompatibilities through routine histotomy and HE staining. Therefore, P(MMA-co-BA)s not only exhibited their unique antibacterial character but also suggested a potential for the safe usage of borneol-modified PMMA frame and devices for further implantation.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP24968794	Poly(acrylonitrile-co-methyl acrylate)		24968-79-4	Price
LS775116	Poly[(methyl methacrylate)-co-(9-H-carbazole-9-ethyl acrylate)]			Price

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