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Antibiofilm Potential of Synthetic 2-amino-5-chlorobenzophenone Schiff Bases and Its Confirmation Through Fluorescence Microscopy

Antibiofilm Potential of Synthetic 2-amino-5-chlorobenzophenone Schiff Bases and Its Confirmation Through Fluorescence Microscopy

Arshia, Anum Khalid Khan, Khalid Mohammed Khan, Ayaz Ahmed, Muhammad Taha, Shahnaz Perveen

Microb Pathog. 2017 Sep;110:497-506.

PMID: 28755874

Abstract:

Antibacterial/antibiofilm potential of microwave-assisted synthetic thirty-three 2-amino-5-chloro benzophenone Schiff bases have been carried out against four bacterial strains i.e. Klebsiella pneumoniae, Proteus mirabilis, Staphylococcus aureus and Streptococcus mutans. Among them compounds 5, 6, 8, 9, 14, 16, 22, 24, 26, and 30-32 showed antibiofilm activities against isolates at less than 100 μg/ml concentrations. These compounds showed enhanced antibiofilm activity against S. aureus as compared to cefixime used as control. However, remaining compounds were found to be active but at higher concentration. Fluorescence microscopy has been employed for confirmation of antibiofilm results. The structures of all synthetic molecules have been characterized on the basis of spectroscopic techniques including 1H NMR, 13C NMR, EI-MS, HREI-MS, and IR spectroscopy and their structure-activity relationship have been established.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP719595-A	2-Amino-5-Chlorobenzophenone		719-59-5	Price

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