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Anticancer Effects of Five Biflavonoids from Ginkgo Biloba L. Male Flowers In Vitro

Anticancer Effects of Five Biflavonoids from Ginkgo Biloba L. Male Flowers In Vitro

Min Li, Bin Li, Zi-Ming Xia, Ying Tian, Dan Zhang, Wen-Jing Rui, Jun-Xing Dong, Feng-Jun Xiao

Molecules. 2019 Apr 16;24(8):1496.

PMID: 30995808

Abstract:

Ginkgo biloba L., an ancient dioecious gymnosperm, is now cultivated worldwide for landscaping and medical purposes. A novel biflavonoid-amentoflavone 7''-O-β-D-glucopyranoside (1)-and four known biflavonoids were isolated and identified from the male flowers of Ginkgo. The anti-proliferative activities of five biflavonoids were evaluated on different cancer lines. Bilobetin (3) and isoginkgetin (4) exhibited better anti-proliferative activities on different cancer lines. Their effects were found to be cell-specific and in a dose and time dependent manner for the most sensitive HeLa cells. The significant morphological changes validated their anticancer effects in a dose-dependent manner. They were capable of arresting the G2/M phase of the cell cycle, inducing the apoptosis of HeLa cells dose-dependently and activating the proapoptotic protein Bax and the executor caspase-3. Bilobetin (3) could also inhibit the antiapoptotic protein Bcl-2. These might be the mechanism underlying their anti-proliferation. In short, bilobetin (3) and isoginkgetin (4) might be the early lead compounds for new anticancer agents.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP521324	Bilobetin		521-32-4	Price
AP548196	Isoginkgetin		548-19-6	Price

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