Home
Resources
Publications
Anticancer Potential of Palladium(II) Complexes With Schiff Bases Derived From 4-Aminoacetophenone Against Melanoma

Anticancer Potential of Palladium(II) Complexes With Schiff Bases Derived From 4-Aminoacetophenone Against Melanoma

Luís Eduardo Sarto, Elba Pereira DE Gois, Gabriela Gomes DE Andrade, Mateus Silveira DE Almeida, Jennifer Tavares Jacon Freitas, Antônio DE Souza Reis Júnior, Lilian Pereira Franco, Claúdia Torres, Eduardo Tonon DE Almeida, etc.

Anticancer Res. 2019 Dec;39(12):6693-6699.

PMID: 31810934

Abstract:

Background/aim:
Melanoma represents a big challenge for clinical treatment. Besides being the most aggressive and the deadliest form of skin cancer, it is often refractory to commonly used anticancer drugs. Hence, developing new anti-cancer agents is crucial to improve refractory melanoma treatment. Studies using palladium(II) complexes have reported antitumor effects on cancer cells. In this study, we aimed to determine the cytotoxic effect of three novel synthesized Pd(II) complexes with Schiff bases derived from 4-aminoacetophenone on the MDA-MB-435 melanoma cell line.
Materials and methods:
Cells were treated with ligand and Pd(II) complexes. Cell viability, morphology and death induction upon treatment were examined.
Results:
Novel synthesized Pd(II) complexes led to decreased viability of cells. They also induced morphological alterations and cell death, mainly in the C3 complex.
Conclusion:
The novel synthesized complexes have a significant cytotoxic effect on cell line MDA-MB-435, especially C3 and can be considered as an antitumor agent for further studies.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP99923	4′-Aminoacetophenone		99-92-3	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: