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Anticancer Properties and Pharmaceutical Applications of Plumbagin: A Review

Anticancer Properties and Pharmaceutical Applications of Plumbagin: A Review

Yuling Liu, Yuee Cai, Chengwei He, Meiwan Chen, Hui Li

Am J Chin Med. 2017;45(3):423-441.

PMID: 28359198

Abstract:

It has been shown that plumbagin, a bioactive naphthoquinone isolated from three major plant families viz. Plumbaginaceae, Ebenceae and Droseraceae, definitively exhibits anticancer potential in diverse cancer cells both in vitro and in vivo. Plumbagin shows antineoplastic effects via multi-channel molecular mechanisms, including the induction of apoptosis and autophagy, the disruption of the cell cycle, the inhibition of invasion and metastasis, and anti-angiogenesis. Plumbagin inhibits the growth of cancer cells mainly through the modulation of the signals of PI3K/Akt/mTOR, AMPK, Ras, and so on. The pharmaceutical applications of plumbagin combined with nanocarriers to achieve better therapeutic efficiency are discussed in this review Among them, liposomes, nanoparticles, microspheres, micelles, and nisosomes are used in cancer treatment. The anticancer study of plumbagin in vivo is also summarized in this review. On the whole, we aim to review the research progress of plumbagin both in pharmacological and pharmaceutical filed, which may provide some reference for further research of plumbagin.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP481425	Plumbagin		481-42-5	Price

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