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Anticonvulsive Activity of (1S)-(-)-verbenone Involving RNA Expression of BDNF, COX-2, and C-Fos

Anticonvulsive Activity of (1S)-(-)-verbenone Involving RNA Expression of BDNF, COX-2, and C-Fos

Cynthia Germoglio Farias de Melo, Paula Regina Rodrigues Salgado, Diogo Vilar da Fonsêca, Renan Marinho Braga, Marcelo Ricardo Dutra Caldas Filho, Ingrid Eulália Vieira de Farias, Hilzeth de Luna Freire Pessôa, etc.

Naunyn Schmiedebergs Arch Pharmacol. 2017 Sep;390(9):863-869.

PMID: 28577050

Abstract:

(1S)-(-)-verbenone (VRB) is a monoterpene present in the essential oils of many plants which has shown therapeutic effect; however, its anticonvulsant activity has not yet been evaluated. The present work sought to investigate the anticonvulsant activity of VRB using pilocarpine and pentylenetetrazole-induced seizure testing; seeking also probable mechanisms of action. VRB caused no significant changes in motor coordination. Also, no significant data was observed in the pilocarpine-induced seizure tests. In the PTZ-induced seizures test, VRB showed anticonvulsant activity at doses of 200 mg/kg i.p. (733 ± 109.4 s) and 250 mg/kg i.p. (648.8 ± 124.5 s) significantly increasing the latency to onset of first seizure as compared with the vehicle group (51.8 ± 2.84 s). Pretreatment with flumazenil (FLU) did not reverse the anticonvulsive effect of VRB; however, it was able to upregulate BDNF and COX-2 genes and downregulate c-fos. The findings suggest that the anticonvulsant effects of VRB may be related to RNA expression modulations of COX-2, BDNF, and c-fos.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1196016	(1S)-(−)-Verbenone		1196-01-6	Price

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