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Antidiabetic Activity of a Standardized Extract (Glucosol) From Lagerstroemia Speciosa Leaves in Type II Diabetics. A Dose-Dependence Study

William V Judy, Siva P Hari, W W Stogsdill, Janet S Judy, Yousry M A Naguib, Richard Passwater

J Ethnopharmacol. 2003 Jul;87(1):115-7.

PMID: 12787964

Abstract:

The antidiabetic activity of an extract from the leaves of Lagerstroemia speciosa standardized to 1% corosolic acid (Glucosol) has been demonstrated in a randomized clinical trial involving Type II diabetics (non-insulin-dependent diabetes mellitus, NIDDM). Subjects received a daily oral dose of Glucosol and blood glucose levels were measured. Glucosol at daily dosages of 32 and 48mg for 2 weeks showed a significant reduction in the blood glucose levels. Glucosol in a soft gel capsule formulation showed a 30% decrease in blood glucose levels compared to a 20% drop seen with dry-powder filled hard gelatin capsule formulation (P<0.001), suggesting that the soft gel formulation has a better bioavailability than a dry-powder formulation.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
CS31041997 Lagerstroemia speciosa leaf dry extract Lagerstroemia speciosa leaf dry extract Price
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