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Antidiabetic and Antiparasitic Potentials: Inhibition Effects of Some Natural Antioxidant Compounds on α-glycosidase, α-amylase and Human Glutathione S-transferase Enzymes

Antidiabetic and Antiparasitic Potentials: Inhibition Effects of Some Natural Antioxidant Compounds on α-glycosidase, α-amylase and Human Glutathione S-transferase Enzymes

İlhami Gulçin, Parham Taslimi, Ayşenur Aygün, Nastaran Sadeghian, Enes Bastem, Omer Irfan Kufrevioglu, Fikret Turkan, Fatih Şen

Int J Biol Macromol. 2018 Nov;119:741-746.

PMID: 30076927

Abstract:

The glutathione S-transferase (GST) was purified from fresh blood erythrocytes using affinity column chromatography. Also, α-amylase from porcine pancreas and α-glycosidase from Saccharomyces cerevisiae were used as target enzymes. In this study, these compounds were tested on α-amylase, α-glycosidase, and GST enzymes and demonstrated effective inhibitor compounds with Ki values in the range of 8.34-40.78 μM against GST, and 120.53-892.36 nM against α-glycosidase. Additionally, the phenolic molecules were tested for the inhibition of α-amylase enzyme which determined effective inhibition profile with IC50 values in the range of 175.01-626.58 nM. Indeed, these molecules can be elective inhibitors of GST, α-glycosidase and α-amylase enzymes as antidiabetic and antiparasitic agents.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR424902	α-Amylase from porcine pancreas			Price

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