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Antidiarrheal Activity of α-terpineol in Mice

Antidiarrheal Activity of α-terpineol in Mice

Polyanna Dos Santos Negreiros, Douglas Soares da Costa, Valdelânia Gomes da Silva, Izabela Borges de Carvalho Lima, Daniel Barbosa Nunes, Francisca Beatriz de Melo Sousa, Thiago de Souza Lopes Araújo, Jand Venes Rolim Medeiros, etc.

Biomed Pharmacother. 2019 Feb;110:631-640.

PMID: 30540974

Abstract:

Diarrhea is one of the leading causes of infant death in the world accounting for high child mortality rate. It is also present in different pathophysiologies related to several etiological agents. The aim of this study is to investigate the antidiarrheal effect of α -Terpineol (α-TPN) in different diarrhea models in rodents. The antidiarrheal effect of α-TPN in the treatment of acute diarrhea and enteropooling induced by castor oil or PGE2 in Swiss mice pretreated orally with saline (NaCl 0.9%), Loperamide (5 mg/kg) and α-TPN (6.25, 12.5, 25 and 50 mg/kg) was analyzed. Additionally, parameters of severity, total weight of faeces and post-treatment for 4 h were evaluated. Modulation of the opioid and cholinergic pathways was performed and intestinal transit model using activated charcoal as marker was also used. The effect of α-TPN on secretory diarrhea was investigated using the model of fluid secretion in intestinal loops isolated from cholera toxin-treated mice. α-TPN showed antidiarrheal effect (*p < 0.05), reducing the total stool amount (*55%, *48%, *44%, *24%) and diarrheal (*47%, *66%; *56%, 10%) respectively for the doses tested. All doses investigated in the enteropooling test presented significant changes (*46%, *78%, *66%, *41% respectively) in relation to the control. α-TPN through the muscarinic pathway reduced the gastrointestinal transit (*31%), besides inhibiting PGE2-induced diarrhea (*39%). α-TPN also reduced fluid formation and loss of Cl- ions, by interacting directly with GM1 receptors and cholera toxin, thus increasing the uptake of intestinal fluids. The results suggest an anti-diarrheal activity of α-TPN due to its anticholinergic action, ability to block PGE2 and GM1 receptors and interaction with cholera toxin in secretory diarrhea, making it a promising candidate drug for the treatment of diarrheal diseases.

Chemicals Related in the Paper:

Catalog Number	Product Name	CAS Number	Price
AP7785537	(+)-α-Terpineol	7785-53-7	Price
AP8000417	Terpineol	8000-41-7	Price
AP98555	α-Terpineol	98-55-5	Price

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