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Antifungal Activity of Saponin-Rich Extracts of Phytolacca Dioica and of the Sapogenins Obtained Through Hydrolysis

Melina Di Liberto, Laura Svetaz, Ricardo L E Furlán, Susana A Zacchino, Carla Delporte, Marco A Novoa, Marcelo Asencio, Bruce K Cassels

Nat Prod Commun. 2010 Jul;5(7):1013-8.

PMID: 20734930

Abstract:

A saponin-rich extract of Phytolacca dioica L. berries, its acid hydrolysate, and its major aglycone, phytolaccagenin, were assayed for antifungal activity against ATCC standard cultures of Candida albicans and Cryptococcus neoformans, and against clinical isolates of these fungi. The activity of the extract was either low or negligible, but the hydrolysate, containing the sapogenins, including phytolaccagenin, and also pure phytolaccagenin, showed promising antifungal potency. Hydrolysis of a natural product extract is shown to be a useful modification leading to improved bioactivity.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1802126 Phytolaccagenin Phytolaccagenin 1802-12-6 Price
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