Home
Resources
Publications
Antifungal Activity of the Piroctone Olamine in Experimental Intra-Abdominal Candidiasis

Antifungal Activity of the Piroctone Olamine in Experimental Intra-Abdominal Candidiasis

Fabíola Maria Marques do Couto, Silene Carneiro do Nascimento, Silvio Francisco Pereira Júnior, Vanessa Karina Alves da Silva, André Ferraz Goiana Leal, Rejane Pereira Neves

Springerplus. 2016 Apr 16;5:468.

PMID: 27119072

Abstract:

This work aimed to evaluate the antifungal activity of piroctone olamine in the treatment of intra-abdominal candidiasis in an experimental model using Swiss mice. The mice (n = 6) were infected by intraperitoneal injection of 0.2 ml of C. albicans (10(7)cells/ml in saline). The animals were observed daily for clinical signs and mortality for 14 days. The treatment with piroctone olamine (0.5 mg/kg) was performed 72 h after infection by intraperitoneal administration. For comparison, a group of animals (n = 6) was treated with amphotericin B (0.5 mg/kg). The mycological diagnosis was made by collecting the liver, spleen and kidneys. Data regarding the fungal growth and mortality were analyzed statistically by Student's t test and analysis of variance (ANOVA), with level of significance set at P < 0.05. The difference in fungal growth scoring between the control group and the treatment groups (piroctone olamine and amphotericin B) was statistically significant (P < 0.05). The difference in fungal growth scoring between the treatment groups (piroctone olamine and amphotericin B) was not statistically significant (P < 0.05).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP68890664-A	Piroctone olamine		68890-66-4	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: