Home
Resources
Publications
Antifungal Garcinia Acid Esters From the Fruits of Garcinia Atroviridis

Antifungal Garcinia Acid Esters From the Fruits of Garcinia Atroviridis

Mukram M Mackeen, Abdul Manaf Ali, Nordin Hj Lajis, Kazuyoshi Kawazu, Hiroe Kikuzaki, Nobuji Nakatani

Z Naturforsch C J Biosci. Mar-Apr 2002;57(3-4):291-5.

PMID: 12064729

Abstract:

Two new garcinia acid derivatives, 2-(butoxycarbonylmethyl)-3-butoxycarbonyl-2-hydroxy-3-propanolide and 1',1"-dibutyl methyl hydroxycitrate, were isolated from the fruits of Garcinia atroviridis guided by TLC bioautography against the fungus Cladosporium herbarum. The structures of these compounds were established by spectral analysis. The former compound represents a unique beta-lactone structure and the latter compound is most likely an artefact of garcinia acid (= hydroxycitric acid). Both compounds showed selective antifungal activity comparable to that of cycloheximide (MID: 0.5 microg/spot) only against C herbarum at the MIDs of 0.4 and 0.8 microg/spot but were inactive against bacteria (Bacillus subtilis, methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli), other fungi (Alternaria sp., Fusarium moniliforme and Aspergillus ochraceous) including the yeast Candida albicans.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP27750136	(+)-Garcinia acid		27750-13-6	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: