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Antifungal Saponins From Bulbs of Garlic, Allium Sativum L. Var. Voghiera

Antifungal Saponins From Bulbs of Garlic, Allium Sativum L. Var. Voghiera

Virginia Lanzotti, Elisa Barile, Vincenzo Antignani, Giuliano Bonanomi, Felice Scala

Phytochemistry. 2012 Jun;78:126-34.

PMID: 22513009

Abstract:

A bioassay-guided phytochemical analysis of the polar extract from the bulbs of garlic, Allium sativum L., var. Voghiera, typical of Voghiera, Ferrara (Italy), allowed the isolation of ten furostanol saponins; voghieroside A1/A2 and voghieroside B1/B2, based on the rare agapanthagenin aglycone; voghieroside C1/C2, based on agigenin aglycone; and voghieroside D1/D2 and E1/E2, based on gitogenin aglycone. In addition, we found two known spirostanol saponins, agigenin 3-O-trisaccharide and gitogenin 3-O-tetrasaccharide. The chemical structures of the isolated compounds were established through a combination of extensive nuclear magnetic resonance, mass spectrometry and chemical analyses. High concentrations of two eugenol diglycosides were also found for the first time in Allium spp. The isolated compounds were evaluated for their antimicrobial activity towards two fungal species, the air-borne pathogen Botrytis cinerea and the antagonistic fungus Trichoderma harzianum.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP511966	Gitogenin		511-96-6	Price
AP55332768	Agigenin		55332-76-8	Price

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