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Antiherpetic Potential of 6-bromoindirubin-3'-acetoxime (BIO-acetoxime) in Human Oral Epithelial Cells

Antiherpetic Potential of 6-bromoindirubin-3'-acetoxime (BIO-acetoxime) in Human Oral Epithelial Cells

Mei-Ju Hsu, Shan-Ling Hung

Arch Virol. 2013 Jun;158(6):1287-96.

PMID: 23392633

Abstract:

Glycogen synthase kinase 3 (GSK-3) functions in the regulation of glycogen metabolism, in the cell cycle, and in immune responses and is targeted by some viruses to favor the viral life cycle. Inhibition of GSK-3 by 6-bromoindirubin-3'-acetoxime (BIO-acetoxime), a synthetic derivative of a compound from the Mediterranean mollusk Hexaplex trunculus, protects cells from varicella infection. In this study, we examined the effects of BIO-acetoxime against herpes simplex virus-1 (HSV-1) infection in human oral epithelial cells, which represent a natural target cell type. The results revealed that BIO-acetoxime relieves HSV-1-induced cytopathic effects and apoptosis. We also found that BIO-acetoxime reduced viral yields and the expression of different classes of viral proteins. Furthermore, addition of BIO-acetoxime before, simultaneously with or after HSV-1 infection significantly reduced viral yields. Collectively, BIO-acetoxime may suppress viral gene expression and protect oral epithelial cells from HSV-1 infection. These results suggest the possible involvement of GSK-3 in HSV-1 infection.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP667463856	BIO-Acetoxime		667463-85-6	Price

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