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Antihypertensive Effects of Fargesin in Vitro and in Vivo via Attenuating Oxidative Stress and Promoting Nitric Oxide Release

Antihypertensive Effects of Fargesin in Vitro and in Vivo via Attenuating Oxidative Stress and Promoting Nitric Oxide Release

Sha Sha, Dandan Xu, Yanwei Wang, Weifang Zhao, Xiaoni Li

Can J Physiol Pharmacol. 2016 Aug;94(8):900-6.

PMID: 27409158

Abstract:

Fargesin, a bioactive neolignan isolated from magnolia plants, is widely used in the treatment of managing rhinitis, inflammation, histamine, sinusitis, and headache. To provide more biological information about fargesin, we investigated the effects of fargesin on rat aortic rings and 2-kidney, 1-clip (2K1C) hypertensive rats. In vitro, fargesin caused concentration-dependent vasorelaxation in rat isolated aortic rings induced by KCl and norepinephrine. The effect was weakened by endothelium denudation and nitric oxide (NO) synthesis inhibition. In vivo, the evolution of systolic blood pressure (SBP) was followed by weekly measurements. Angiotensin II (Ang II) and endothelin (ET) levels, NO and nitric oxide synthase (NOS), and plasma and liver oxidative stress markers were determined at the end of the experimental period. After 5 weeks of fargesin treatment, we found that fargesin treatment reduced SBP, cardiac hypertrophy, and Ang II and ET levels of hypertensive rats. Increased NOS activity and NO level were observed in fargesin-treated rats. Normalisation of plasma MDA concentrations and improvement of the antioxidant defence system in plasma and liver accompanied the antihypertensive effect of fargesin. Taken together, these results provided substantial evidences that fargesin has antihypertensive effect in 2K1C hypertensive rats via inhibiting oxidative stress and promoting NO release.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP31008192	Fargesin		31008-19-2	Price

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