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Antihypertensive Effects of KW-3902, an Adenosine A1-receptor Antagonist, in Dahl Salt-Sensitive Rats

Antihypertensive Effects of KW-3902, an Adenosine A1-receptor Antagonist, in Dahl Salt-Sensitive Rats

H Nomura, K Nagashima, H Kusaka, A Karasawa

Jpn J Pharmacol. 1995 Aug;68(4):389-96.

PMID: 8531413

Abstract:

We determined the effects of KW-3902 (8-(noradamantan-3-yl)-1,3- dipropylxanthine), a novel adenosine A1-receptor antagonist, on the development of hypertension in Dahl salt-sensitive (Dahl-S) rats. KW-3902 (0.00017% w/w-0.017% w/w), fed with the diet, prevented the development of hypertension at 2-6 weeks in response to the high (8% w/w) NaCl diet. KW-3902 increased urine volume and sodium excretion and attenuated cardiac hypertrophy. In another series of the experiments employing the clearance method, KW-3902 (0.1 mg/kg, i.v.) increased urine volume, sodium excretion and lithium clearance in anesthetized Dahl-S rats. These results suggest that the antihypertensive effect of KW-3902 in Dahl-S rats is mediated via its natriuretic effect, the site of action being, at least partly, the proximal tubule. The adenosine A1-receptor antagonist may be effective for the treatment of salt-sensitive hypertension.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP136199025	KW-3902		136199-02-5	Price

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