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Antiinflammatory and Lipoxygenase Inhibitory Compounds From Vitex Agnus-Castus

Antiinflammatory and Lipoxygenase Inhibitory Compounds From Vitex Agnus-Castus

M Iqbal Choudhary, Azizuddin, Saima Jalil, Sarfraz Ahmad Nawaz, Khalid Mohammed Khan, Rasool Bakhsh Tareen, Atta-ur-Rahman

Phytother Res. 2009 Sep;23(9):1336-9.

PMID: 19173281

Abstract:

Several secondary metabolites, artemetin (1), casticin (2), 3,3'-dihydroxy-5,6,7,4'-tetramethoxy flavon (3), penduletin (4), methyl 4-hydroxybenzoate (5), p-hydroxybenzoic acid (6), methyl 3,4-dihydroxybenzoate (7), 5-hydroxy-2-methoxybenzoic acid (8), vanillic acid (9) and 3,4-dihydroxybenzoic acid (10) were isolated from a folkloric medicinal plant, Vitex agnus-castus. The structures of compounds 1-10 were identified with the help of spectroscopic techniques. Compounds 3-10 were isolated for the first time from this plant. These compounds were screened for their antiinflammatory and lipoxygenase inhibitory activities. Compounds 6, 7 and 10 were found to have significant antiinflammatory activity in a cell-based contemporary assay, whereas compounds 1 and 2 exhibited a potent lipoxygenase inhibition.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP569802	Penduletin		569-80-2	Price

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