Home
Resources
Publications
Antiinflammatory Effect of Oldenlandia Diffusa and Its Constituent, Hentriacontane, Through Suppression of caspase-1 Activation in Mouse Peritoneal Macrophages

Antiinflammatory Effect of Oldenlandia Diffusa and Its Constituent, Hentriacontane, Through Suppression of caspase-1 Activation in Mouse Peritoneal Macrophages

Su-Jin Kim, Won-Seok Chung, Sung-Soo Kim, Seong-Gyu Ko, Jae-Young Um

Phytother Res. 2011 Oct;25(10):1537-46.

PMID: 21394806

Abstract:

Oldenlandia diffusa (OD) has been used as a natural drug for the treatment of cancer in Asia and specifically in Korea. However, the antiinflammatory mechanisms employed by OD have yet to be completely understood. This study attempted to determine the effects of OD and hentriacontane, one of the constituent compounds of OD, on lipopolysaccharide (LPS)-induced inflammatory responses in mouse peritoneal macrophages. The findings of this study showed that OD inhibited the production of tumor necrosis factor (TNF)-α, interleukin (IL)-6 and prostaglandin E(2) (PGE(2)). The OD inhibited the enhanced levels of cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) induced by LPS. It was shown that the antiinflammatory effect of OD occurs via the regulation of the activation of nuclear factor (NF)-κB and caspase-1. Moreover, hentriacontane was shown to ameliorate the expression of inflammatory mediators (TNF-α, IL-6, PGE(2), COX-2 and iNOS) and the activation of NF-κB and caspase-1 in LPS-stimulated peritoneal macrophages. These results provide novel insights into the pharmacological actions of OD as a potential candidate for the development of new drugs for the treatment of inflammatory diseases.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP630046	Hentriacontane		630-04-6	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: