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Antimicrobial Activity of Globulol Isolated From the Fruits of Eucalyptus Globulus Labill

Manliang Tan, Ligang Zhou, Yongfu Huang, Ye Wang, Xiaojiang Hao, Jingguo Wang

Nat Prod Res. 2008 May 10;22(7):569-75.

PMID: 18569693

Abstract:

An antimicrobial sesquiterpene was separated by bioassay-guided isolation from the petroleum ether fraction of the ethanol crude extract of Eucalyptus globulus Labill (Myrtaceae) fruits, and was identified as globulol by physicochemical properties and spectroscopic analysis. Mycelial growth method revealed that the median effective inhibitory concentration (IC50) values of globulol on Alternaria solani, Fusarium oxysporum f.sp. niverum, F. graminearum, Rhizoctonia solani and Venturia pirina were 47.1 microg mL(-1), 114.3 microg mL(-1), 53.4 microg mL(-1), 56.9 microg mL(-1), 32.1 microg mL(-1) and 21.8 microg mL(-1), respectively. MTT-colorimetric assay revealed that IC50 values of globulol on Xanthomonas vesicatoria and Bacillus subtilis were 158.0 microg mL(-1) and 737.2 microg mL(-1), respectively. The results indicated that globulol could be a main antimicrobial compound in the ethanol crude extract of E. globulus fruits.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP489418 (−)-Globulol (−)-Globulol 489-41-8 Price
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