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Antimicrobial and Antioxidant Activities and Effect of 1-hexadecene Addition on Palmarumycin C2 and C3 Yields in Liquid Culture of Endophytic Fungus Berkleasmium Sp. Dzf12

Antimicrobial and Antioxidant Activities and Effect of 1-hexadecene Addition on Palmarumycin C2 and C3 Yields in Liquid Culture of Endophytic Fungus Berkleasmium Sp. Dzf12

Yan Mou, Jiajia Meng, Xiaoxiang Fu, Xiaohan Wang, Jin Tian, Mingan Wang, Youliang Peng, Ligang Zhou

Molecules. 2013 Dec 13;18(12):15587-99.

PMID: 24352015

Abstract:

Two spirobisnaphthalenes, namely palmarumycins C2 and C3, were isolated from cultures of the endophytic fungus Berkleasmium sp. Dzf12 after treatment with 1-hexadecene. After addition of 1-hexadecene at 10% to the medium on day 6 of culture, the maximal yields of palmarumycins C2 and C3 were obtained as 0.40 g/L and 1.19 g/L, which were 40.00 fold and 59.50 fold higher, respectively, in comparison with those of the control (0.01 g/L and 0.02 g/L). The results indicated that addition of 1-hexadecene can be an effective strategy for enhancing the production of palmarumycins C2 and C3 in liquid culture of endophytic fungus Berkleasmium sp. Dzf12. Palmarumycin C3 exhibited stronger antimicrobial and antioxidant activities than palmarumycin C2.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP629732	1-Hexadecene		629-73-2	Price

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