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Antimicrobial Effect of Sophoraflavanone G Isolated From Sophora Flavescens Against Mutans Streptococci

Antimicrobial Effect of Sophoraflavanone G Isolated From Sophora Flavescens Against Mutans Streptococci

Chun Sung Kim, Soon-Nang Park, Sug-Joon Ahn, Young-Woo Seo, Young-Ju Lee, Yun Kyong Lim, Marcelo Oliveira Freire, Eugene Cho, Joong-Ki Kook

Anaerobe. 2013 Feb;19:17-21.

PMID: 23178373

Abstract:

In this study, the antibacterial properties of sophoraflavanone G isolated from the methanol extract of Sophora flavescens were tested against 16 strains of mutans streptococci to screen and determine the optimal concentration of anti-caries natural extract. The antimicrobial activity was evaluated by measuring minimum bactericidal concentration (MBC). The cell viability of normal human gingival fibroblast (NHGF) cells was tested using the methyl thiazolyl tetrazolium assay after exposure to sophoraflavanone G. The data showed that sophoraflavanone G had a remarkable antimicrobial effect on the bacteria tested with an MBC ranging from 0.5 μg/ml to 4 μg/ml. Sophoraflavanone G had no cytotoxic effect on NHGF cells at concentrations where it produced an antimicrobial effect. These findings demonstrate that sophoraflavanone G has strong antimicrobial activity against mutans streptococci and could be useful in the development of novel oral hygiene products, such as a gargle solution or dentifrice.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP97938302	Sophoraflavanone G		97938-30-2	Price

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