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Antimicrobial Peptides in Animals and Their Role in Host Defences

Antimicrobial Peptides in Animals and Their Role in Host Defences

Kim A Brogden, Mark Ackermann, Paul B McCray Jr, Brian F Tack

Int J Antimicrob Agents. 2003 Nov;22(5):465-78.

PMID: 14602364

Abstract:

Domesticated animals have a large variety of antimicrobial peptides that serve as natural innate barriers limiting microbial infection or, in some instances, act as an integral component in response to inflammation or microbial infection. These peptides differ in size, composition, mechanisms of activity and range of antimicrobial specificities. They are expressed in many tissues, polymorphonuclear leukocytes, macrophages and mucosal epithelial cells. There is a small group of anionic antimicrobial peptides found in ruminants and a much larger group of cationic antimicrobial peptides found in all domesticated animals. The cationic peptides include linear, helical peptides, linear peptides rich in proline and cysteine-stabilized peptides with a beta-sheet and are commonly referred to as cathelicidins and defensins. These peptides are generally broad-spectrum for Gram-positive bacteria, Gram-negative bacteria and fungi (e.g. myeloid antimicrobial peptides, alpha-, beta-defensins, and protegrins) or are specific to one of these groups (e.g. porcine cecropin P1, Bac5, Bac7, PR-39 and prophenin).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP125667961	Cecropin P1 Porcine		125667-96-1	Price

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