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[Antimicrobial Resistance and Clinical Significant Resistance Mechanisms of Salmonella Isolated in 2014-2018 in St.Petersburg, Russia]

[Antimicrobial Resistance and Clinical Significant Resistance Mechanisms of Salmonella Isolated in 2014-2018 in St.Petersburg, Russia]

S A Egorova, L A Kaftyreva, L V Suzhaeva, A V Zabrovskaia, E V Voitenkova, Z N Matveeva, Y V Ostankova, I V Likhachev, N V Satosova, R V Kitsbabashvili, E V Smirnova, L I Semchenkova, T E Bystraya, S E Sokol'nik, etc.

Klin Lab Diagn. 2019;64(10):620-626.

PMID: 31742956

Abstract:

The article presents the results of antimicrobial resistance monitoring of Salmonella isolated from children and adults with diarrhea in St. Petersburg in 2014-2018. In 746 isolates of 42 serovars more than 90,0% belonged to three: S. enteritidis (79,6%), S. typhimurium (6,8%) and S. infantis (3,8%). The antimicrobial susceptibility testing (according the EUCAST) to 7 classes of antimicrobials revealed the resistance in 78,6% of Salmonella. Low-level quinolone resistance (MIC of ciprofloxacin 0,12-0,5 mg/l) was detected in 63,3% isolates (S. enteritidis -71,0%, S. typhimurium - 15,7%, S. infantis - 89,3%) and was due to five kinds of single nucleotide substitutions in gyrA: Asp87Tyr - 36,1% of studied isolates (only S. infantis); Ser83Phe - 22,2% (only S. enteritidis); Asp87Asn - 19,4% (S. enteritidis, S. typhimurium, S. hadar, S. newport); Ser83Tyr -11,1% (S. enteritidis and S. infantis) and Asp87Gly - 8,3% (only S. enteritidis). Only in one S. kentucky isolate with high-level fluoroquinolone resistance (MIC of ciprofloxacin > 8,0 mg/l) two substitutions (Ser83Phe and Asp87Asn) were detected. Two Salmonella isolates (S. typhimurium and S. corvallis) had plasmid-mediated quinolone resistance (qnrS). Extended-spectrum cephalosporin resistance was found in 6 Salmonella serovars (1,6%). The bla-genes were detected: of genetic group CTX-M1 - in 10 isolates (serovars S. typhimurium, S. enteritidis, S. abony, S. coeln and S. virchow), CTX-M2 - in 2 S. typhimurium isolates, CTX-M9 - in three S. enteritidis isolates. In one S. typhimurium CTX-M1 and CTX-M2 were detected. The gene of CMY-2 (molecular class C cephalosporinase) was revealed in two isolates (S. newport and S. enteritidis). Our study showed that Salmonella (the main bacterial pathogen of acute diarrhea in children and adults) isolated in Saint-Petersburg had antimicrobial resistance to drugs of choice for salmonellosis treatment.

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Catalog Number	Product Name	Structure	CAS Number	Price
AP1052236868	(S)-5-Allyl-2-oxabicyclo[3.3.0]oct-8-ene		1052236-86-8	Price
AP74046074	S(+)-γ-Vigabatrin		74046-07-4	Price

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