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Antioxidant and Neurosedative Properties of Polyphenols and Iridoids From Lippia Alba

Thierry Hennebelle, Sevser Sahpaz, Bernard Gressier, Henry Joseph, François Bailleul

Phytother Res. 2008 Feb;22(2):256-8.

PMID: 17705148

Abstract:

The neurosedative and antioxidative properties of some major compounds isolated from a citral chemotype of Lippia alba were investigated. Binding assays were performed on two CNS inhibitory targets: benzodiazepine and GABA(A) receptors. The most active compound was luteolin-7-diglucuronide, with half maximal inhibitory concentrations (IC(50)) of 101 and 40 microm, respectively. Fifteen compounds isolated from Lippia alba were tested for their radical scavenging capacities against DPPH. Four of the major compounds (verbascoside, calceolarioside E, luteolin-7-diglucuronide and theveside) were also tested for their antioxidant activity against superoxide radical-anion in cell-free (hypoxanthine-xanthine oxidase) and cellular (PMA-stimulated neutrophil granulocytes) systems.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP96400452 Luteolin 7-diglucuronide Luteolin 7-diglucuronide 96400-45-2 Price
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