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Antiparasitic Efficacy of Artemisia Absinthium, Toltrazuril and Amprolium Against Intestinal Coccidiosis in Goats

Antiparasitic Efficacy of Artemisia Absinthium, Toltrazuril and Amprolium Against Intestinal Coccidiosis in Goats

A Iqbal, K A Tariq, V S Wazir, R Singh

J Parasit Dis. 2013 Apr;37(1):88-93.

PMID: 24431547

Abstract:

Various anti-protozoal dugs have been popularly used in the treatment of goat coccidiosis; however, residual effects are well noticed in host animals. The present study was undertaken with the objective to evaluate the anticoccidial efficacy of Artemisia absinthium, as a safe alternative in comparison to two conventional anticoccidial drugs (toltrazuril and amprolium) in goats (Capra hircus) naturally infected with Eimeria spp. (>5,000 oocyst per gram of faeces). Goat kids (1-3 month old, 10 kg body weight) were randomly allocated into five groups (eight kids each). Group A was negative for coccidiosis and was retained as uninfected and untreated (negative control). Group B was infected and was kept untreated (positive control). Group C was given a single oral dose of toltrazuril (Baycox 5 %) at 20 mg kg(-1) BW (IM). Group D received amprolium soluble powder 20 w/w% at 50 mg kg(-1) BW 5 days daily. Group E was given a single dose of ethanolic extract of Artemisia absinthium at 2 g kg(-1) BW. Clinical signs, body-weight gain (BWG) and number of oocysts per gram faeces (OPG) were monitored daily for 30 days post treatment (DPT). The OPG was highly reduced as early as 7 DPT and there was a marked improvement in body weight gain (7 DPT) and faster clinical recovery (3-6 DPT) in the toltrazuril treated kids compared to amprolium and Artemisia absinthium treated groups (P ≤ 0.05). In Artemisia absinthium treated kids, the oocysts continued to be in faeces up to 28th day post treatment indicating that ethanolic extract of herb was less efficacious against caprine coccidiosis as compared to amprolium and toltrazuril. From the observations of the present study it can be concluded that control of goat coccidiosis through single treatment of toltrazuril was highly effective as compared to the other two treatments. However, integrated control involving pasture management, chemical and herbal control will be a more realistic and sustainable means of controlling coccidiosis in goats. Further studies at different doses and concentrations using different solvent preparations of the plant extract are recommended to arrive at a certain conclusion about the anti-coccidial efficacy of Artemisia absinthium, which has been reported to be highly effective against other parasites in ruminants.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP137882	Amprolium		137-88-2	Price

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