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Antiparasitic Structure-Activity Relationships of Congocidine Derivatives

M Bialer, J El-On, B Yagen, R Mechoulam

J Pharm Sci. 1981 Jul;70(7):822-4.

PMID: 6267245

Abstract:

Several congocidine analogs were synthesized and tested for in vivo activity against Trypanosoma congolense and in vitro activity against amastigotes of Leishmania tropica. The tripyrrole derivative, beta-([N-methyl-4-[N-methyl-4-(guanidinoacetamido)pyrrole-2-carboxamido]pyrrole -2-carboxamido]pyrrole-2-carboxamido)butyroamidine dihydrochloride, was less toxic and more active than congocidine. The guanidinoacetyl moiety appears to be a structural requirement for antiparasitic activity in the congocidine series.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP18133227 Netropsin dihydrochloride Netropsin dihydrochloride 18133-22-7 Price
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