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Antiplatelet Activity of L-sulforaphane by Regulation of Platelet Activation Factors, Glycoprotein IIb/IIIa and Thromboxane A2

Antiplatelet Activity of L-sulforaphane by Regulation of Platelet Activation Factors, Glycoprotein IIb/IIIa and Thromboxane A2

Chung-Hun Oh, Jang-In Shin, Sang Joon Mo, Sung-Jo Yun, Sung-Hoon Kim, Yun-Hee Rhee

Blood Coagul Fibrinolysis. 2013 Jul;24(5):498-504.

PMID: 23412354

Abstract:

L-sulforaphane was identified as an anticarcinogen that could produce quinine reductase and a phase II detoxification enzyme. In recent decades, multi-effects of L-sulforaphane may have been investigated, but, to the authors' knowledge, the antiplatelet activation of L-sulforaphane has not been studied yet.In this study, 2 μg/ml of collagen, 50 μg/ml of ADP and 5 μg/ml of thrombin were used for platelet aggregations with or without L-sulforaphane. L-sulforaphane inhibited the platelet aggregation dose-dependently. Among these platelet activators, collagen was most inhibited by L-sulforaphane, which markedly decreased collagen-induced glycoprotein IIb/IIIa activation and thromboxane A2 (TxA2) formation in vitro. L-sulforaphane also reduced the collagen and epinephrine-induced pulmonary embolism, but did not affect prothrombin time (PT) in vivo. This finding demonstrated that L-sulforaphane inhibited the platelet activation through an intrinsic pathway.L-sulforaphane had a beneficial effect on various pathophysiological pathways of the collagen-induced platelet aggregation and thrombus formation as a selective inhibition of cyclooxygenase and glycoprotein IIb/IIIa antagonist. Thus, we recommend L-sulforaphane as a potential antithrombotic drug.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP142825103	L-Sulforaphane		142825-10-3	Price

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