0

Antiproliferative Effect of Valproic Acid and 5,7-dimethoxycoumarin Against A2058 Human Melanoma Cells

Daniel Wolny, Ewa Chodurek, Zofia Dzierzewicz

Acta Pol Pharm. Nov-Dec 2014;71(6):1056-9.

PMID: 25745779

Abstract:

Melanoma is one of the most malignant tumors of a dangerous high incidence and high metastatic potential. It grows quickly and in an advanced stage is resistant to radio-, chemo- and immunotherapy, which makes it difficult to cure. Therefore, research efforts are focused on the development of new therapeutics or chemopreventive strategies. The aim of the study was to investigate whether the valproic acid and 5,7-dimethoxycoumarin have an antiproliferative activity against A2058 human melanoma cell line. Investigated compounds inhibited the proliferation of cells, however, no synergistic effect of their co-administration was observed.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP487069-B 5,7-Dimethoxycoumarin 5,7-Dimethoxycoumarin 487-06-9 Price
qrcode