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Antiproliferative Effects of Daucane Esters From Ferula Communis and F. Arrigonii on Human Colon Cancer Cell Lines

F Poli, G Appendino, G Sacchetti, M Ballero, N Maggiano, F O Ranelletti

Phytother Res. 2005 Feb;19(2):152-7.

PMID: 15852493

Abstract:

Certain jaesekanadiol p-hydroxy- and p-methoxybenzoates - typical of Ferula communis and Ferula arrigonii sardinian plants - show antiproliferative activity on human colon cancer less. The inhibitory doses 50%, calculated after 72 h of treatment, revealed that the antiproliferative capacity of the compounds was in the following descending order: ferutinin > 2alpha-OH-ferutidin > ferutidin > siol anisate > lapiferin > jaeskeanadiol. Evidence is presented that interaction with type II estrogen-binding sites (EBS) underlies this activity.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
CS3102832 Lapiferine Lapiferine Price
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