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Antiproliferative Effects of Melatonin and CGP 52608

Antiproliferative Effects of Melatonin and CGP 52608

M Karasek, M Pawlikowski

Biol Signals Recept. Jan-Apr 1999;8(1-2):75-8.

PMID: 10085466

Abstract:

The antiproliferative effects of melatonin and CGP 52608, an exogenous ligand for RZR/ROR receptors, are compared in the present paper. Both compounds exerted similar inhibitory effects on the proliferation of neoplastic cells in mouse colonic adenocarcinoma, DU 145 human prostate cancer, MCF-7 human breast carcinoma, and rat diethylstilbestrol-induced prolactinoma. Although it has been suggested that melatonin may influence the proliferation of tumor cells via RZR/ROR receptors, it cannot be excluded that the antiproliferative effects of melatonin and CGP 52608 are unrelated and mediated by different intracellular mechanisms.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP87958676	CGP 52608		87958-67-6	Price

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