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Antipsychotic-like Profile of CIQ Isomers in Animal Models of Schizophrenia

Antipsychotic-like Profile of CIQ Isomers in Animal Models of Schizophrenia

Pushparaj Gawai, Rohit Upadhyay, Sukanya G Gakare, Lopmudra Sarode, Shashank Dravid, Rajesh R Ugale

Behav Pharmacol. 2019 Dec 18.

PMID: 31860561

Abstract:

Earlier, we have shown the efficacy of racemic (±) CIQ, a positive allosteric modulator of GluN2C/2D receptor against MK-801 induced impairment of prepulse inhibition as well as working memory. The present study investigated the antipsychotic-like profile of different CIQ (±, +, -) isomers against schizophrenia-like symptoms in series of behavioural animal models like apomorphine climbing, social isolation behaviour and NMDA receptor antagonist MK-801 induced cognitive deficits. Further, we also tested CIQ (±, +, -) isomers in neurodevelopmental model against MK-801induced deficits using open field test, Y-maze test and novel object recognition test. CIQ (±, +, -) isomers decreased climbing behaviour, increased social interaction and improved the MK-801 induced deficits in working memory in Y-maze. Further, CIQ (±, +) but not CIQ (-) improved the recognition memory in novel object recognition test as well as reduced hyperlocomotion and stereotyped behaviour. We conclude that CIQ (±, +) but not CIQ (-) exhibit the significant antipsychotic-like profile.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP486427172	CIQ		486427-17-2	Price

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