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Antitumor Activity of Unsaturated Fatty Acid Esters of 4'-demethyldeoxypodophyllotoxin

Young-Jae You, Yong Kim, Nguyen-Hai Nam, Byung-Zun Ahn

Bioorg Med Chem Lett. 2003 Aug 18;13(16):2629-32.

PMID: 12873481

Abstract:

Unsaturated fatty acid esters of 4'-demethyldeoxypodophyllotoxin (DDPT) were prepared and tested for antitumor activity. The esters showed increased in vivo antitumor activity despite the lower in vitro activity than DDPT. Especially, the ester (DFE12) of all-cis-11,14-eicosadienoic acid was much better (IR, 83%) than VP-16 (IR, 60%) without loss of body weight. Unsaturated fatty acids could be evaluated to be good carrier vehicles of DDPT.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP2091396 cis-11,14-Eicosadienoic acid cis-11,14-Eicosadienoic acid 2091-39-6 Price
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