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Antiviral Effect of Lithium Chloride on Infection of Cells by Canine Parvovirus

Antiviral Effect of Lithium Chloride on Infection of Cells by Canine Parvovirus

Pei Zhou, Xinliang Fu, Zhongshan Yan, Bo Fang, San Huang, Cheng Fu, Malin Hong, Shoujun Li

Arch Virol. 2015 Nov;160(11):2799-805.

PMID: 26315688

Abstract:

Canine parvovirus type 2 causes significant viral disease in dogs, with high morbidity, high infectivity, and high mortality. Lithium chloride is a potential antiviral drug for viruses. We determined the antiviral effect of Lithium Chloride on canine parvovirus type 2 in feline kidney cells. The viral DNA and proteins of canine parvovirus were suppressed in a dose-dependent manner by lithium chloride. Further investigation verified that viral entry into cells was inhibited in a dose-dependent manner by lithium chloride. These results indicated that lithium chloride could be a potential antiviral drug for curing dogs with canine parvovirus infection. The specific steps of canine parvovirus entry into cells that are affected by lithium chloride and its antiviral effect in vivo should be explored in future studies.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42513	Lithium-7Li chloride			Price

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