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Apigenin Inhibits IL-31 Cytokine in Human Mast Cell and Mouse Skin Tissues

Apigenin Inhibits IL-31 Cytokine in Human Mast Cell and Mouse Skin Tissues

Denis Nchang Che, Byoung Ok Cho, Jae Young Shin, Hyun Ju Kang, Ji-Su Kim, Hyeonhwa Oh, Young-Soo Kim, Seon Il Jang

Molecules. 2019 Apr 2;24(7):1290.

PMID: 30987029

Abstract:

IL-31 is a recently discovered cytokine that is produced not only in T-cells but also in mast cells. It is strongly implicated to play a key role in inflammatory diseases and in the pathogenesis of itch in atopic dermatitis. Apigenin, a flavonoid of plant origin has numerous biological applications. In this study, we showed that apigenin modulates IL-31 mRNA, protein expression, and release in stimulated human mast (HMC-1) by inhibiting the phosphorylation activation of MAPK and NF-κB. To determine whether apigenin has similar effects in vivo, using Compound 48/80, we developed an atopic dermatitis itch model in mice and found an increase in IL-31 expression in the skin. We also revealed that apigenin prevents the infiltration and degranulation of mast cells and suppressed mRNA and protein expression of IL-31 in the skin of mice. These results provide a new suggestion of the potential applicability of apigenin for treatment of various inflammatory diseases and itch mediated by IL-31.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413393	IL-31 human			Price

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