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Apolipoprotein A-II Suppressed Concanavalin A-induced Hepatitis via the Inhibition of CD4 T Cell Function

Apolipoprotein A-II Suppressed Concanavalin A-induced Hepatitis via the Inhibition of CD4 T Cell Function

Junji Yamashita, Chiaki Iwamura, Tetsuya Sasaki, Kunitoshi Mitsumori, Kazutoshi Ohshima, Kaori Hada, Naoko Hara, Munehisa Takahashi, Yoshiaki Kaneshiro, Hitoshi Tanaka, Kenji Kaneko, Toshinori Nakayama

J Immunol. 2011 Mar 15;186(6):3410-20.

PMID: 21300819

Abstract:

Con A-induced hepatitis has been used as a model of human autoimmune or viral hepatitis. During the process of identifying immunologically bioactive proteins in human plasma, we found that apolipoprotein A-II (ApoA-II), the second major apolipoprotein of high-density lipoprotein, inhibited the production of IFN-γ by Con A-stimulated mouse and human CD4 T cells. Con A-induced hepatitis was attenuated by the administration of ApoA-II. The beneficial effect of ApoA-II was associated with reduced leukocyte infiltration and decreased production of T cell-related cytokines and chemokines in the liver. ApoA-II inhibited the Con A-induced activation of ERK-MAPK and nuclear translocation of NFAT in CD4 T cells. Interestingly, exacerbated hepatitis was observed in ApoA-II-deficient mice, indicating that ApoA-II plays a suppressive role in Con A-induced hepatitis under physiological conditions. Moreover, the administration of ApoA-II after the onset of Con A-induced hepatitis was sufficient to suppress disease. Thus, the therapeutic effect of ApoA-II could be useful for patients with CD4 T cell-related autoimmune and viral hepatitis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4247070	Apolipoprotein A-II from human plasma			Price

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