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Apolipoprotein A-IV: A Multifunctional Protein Involved in Protection Against Atherosclerosis and Diabetes

Apolipoprotein A-IV: A Multifunctional Protein Involved in Protection Against Atherosclerosis and Diabetes

Jie Qu, Chih-Wei Ko, Patrick Tso, Aditi Bhargava

Cells. 2019 Apr 5;8(4):319.

PMID: 30959835

Abstract:

Apolipoprotein A-IV (apoA-IV) is a lipid-binding protein, which is primarily synthesized in the small intestine, packaged into chylomicrons, and secreted into intestinal lymph during fat absorption. In the circulation, apoA-IV is present on chylomicron remnants, high-density lipoproteins, and also in lipid-free form. ApoA-IV is involved in a myriad of physiological processes such as lipid absorption and metabolism, anti-atherosclerosis, platelet aggregation and thrombosis, glucose homeostasis, and food intake. ApoA-IV deficiency is associated with atherosclerosis and diabetes, which renders it as a potential therapeutic target for treatment of these diseases. While much has been learned about the physiological functions of apoA-IV using rodent models, the action of apoA-IV at the cellular and molecular levels is less understood, let alone apoA-IV-interacting partners. In this review, we will summarize the findings on the molecular function of apoA-IV and apoA-IV-interacting proteins. The information will shed light on the discovery of apoA-IV receptors and the understanding of the molecular mechanism underlying its mode of action.

Chemicals Related in the Paper:

Catalog Number	Product Name	CAS Number	Price
AP1118032	Azidotrimethyltin(IV)	1118-03-2	Price
AP6148487	Bromotrimethyllead(IV)	6148-48-7	Price
AP993522	Hexamethyldigermanium(IV)	993-52-2	Price

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