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Apoptotic Activities of C2-ceramide and C2-dihydroceramide Homologues Against HL-60 Cells

Apoptotic Activities of C2-ceramide and C2-dihydroceramide Homologues Against HL-60 Cells

Keiji Shikata, Hayato Niiro, Hideki Azuma, Kenji Ogino, Taro Tachibana

Bioorg Med Chem. 2003 Jul 3;11(13):2723-8.

PMID: 12788346

Abstract:

The apoptotic activities of non-natural ceramide homologues, C2-homo-ceramide, C2-homo-dihydroceramide, C2-bishomo-ceramide and C2-bishomo-dihydroceramide, were examined using human leukemia HL-60 cells. The apoptotic activity was in order of C2-ceramide>C2-homo-ceramide approximately C2-bishomo-ceramide and the activities of the L-erythro- and D-erythro-ceramide homologues were similar. The morphological features of the cells, DNA fragmentations, proteolytic processing of pro-caspase-3 and the cleavage of PARP as the result of treatments with these homologues indicated that cell death was induced by apoptosis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4243046	Dihydroceramide C2			Price

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