Home
Resources
Publications
Application of Electrolysis for Detoxification of an Antineoplastic in Urine

Application of Electrolysis for Detoxification of an Antineoplastic in Urine

Toyohide Kobayashi, Jun Hirose, Kouichi Sano, Ryuji Kato, Yoshio Ijiri, Hiroya Takiuchi, Kazuhiko Tanaka, Emi Goto, Hiroshi Tamai, Takashi Nakano

Ecotoxicol Environ Saf. 2012 Apr;78:123-7.

PMID: 22154144

Abstract:

Antineoplastics in excreta from patients have been considered to be one of the origins of cytotoxic, carcinogenic, teratogenic, and mutagenic contaminants in surface water. Recent studies have demonstrated that antineoplastics in clinical wastewater can be detoxified by electrolysis. In this study, to develop a method for the detoxification of antineoplastics in excreta, methotrexate solution in the presence of human urine was electrolyzed and evaluated. We found that urine inhibits detoxification by electrolysis; however, this inhibition decreased by diluting urine. In urine samples, the concentrations of active chlorine generated by anodic oxidation from 0.9% NaCl solution for inactivation of antineoplastics increased in dilution-dependent and time-dependent manner. These results indicate that electrolysis with platinum-based iridium oxide composite electrode is a possible method for the detoxification of a certain antineoplastic in urine.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP59052-A	Methotrexate solution		59-05-2	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: