Home
Resources
Publications
Application of Liquid chromatography/ion Trap Mass Spectrometry to the Characterization of the Related Substances of Clarithromycin

Application of Liquid chromatography/ion Trap Mass Spectrometry to the Characterization of the Related Substances of Clarithromycin

Stefanie Leonard, Monica Ferraro, Erwin Adams, Jos Hoogmartens, Ann Van Schepdael

Rapid Commun Mass Spectrom. 2006;20(20):3101-10.

PMID: 16991103

Abstract:

A selective reversed-phase liquid chromatography/mass spectrometry (LC/MS(n)) method was developed for the characterization of components of the semi-synthetic macrolide clarithromycin. Mass spectral data were acquired online on a LCQ ion trap mass spectrometer equipped with an electrospray ionization source operated in the positive ion mode. One unknown compound was structurally elucidated and two other unknowns were characterized using the MS/MS and MS(n) collision-induced dissociation spectra of reference substances as interpretative templates, combined with knowledge of the nature of functional group fragmentation behaviour. Given the importance attached to the identification of impurities of unknown identity in pharmaceutical substances, this study is useful for companies producing clarithromycin.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP81103119-A	Clarithromycin Identity		81103-11-9	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: