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Applications of Paired Ion High-Pressure Liquid Chromatography: Quantitative Determination of Potassium Guaiacolsulfonate and Other Ingredients in Cough Syrups

Applications of Paired Ion High-Pressure Liquid Chromatography: Quantitative Determination of Potassium Guaiacolsulfonate and Other Ingredients in Cough Syrups

V D Gupta

J Pharm Sci. 1979 Jan;68(1):118-20.

PMID: 758448

Abstract:

A method for the quantitative determination of potassium guaiacolsulfonate and phenylephrine hydrochloride in commercial dosage forms was developed. The method is based on paired ion high-pressure liquid chromatography with tetrabutylammonium as the counterion. The method not only separates potassium guaiacolsulfonate from phenylephrine hydrochloride but also from some other ingredients: chlorpheniramine maleate, sodium benzoate, colors, and flavors. Furthermore, two isomers of potassium guaiacolsulfonate, potassium salts of 4- and 5-guaiacolsulfonic acid, also separate from each other. The method was tried on five different commercial dosage forms (all with different colors) with excellent results on three. In the other two samples, which also contained codeine, three may have been a stability problem.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP78247491	Potassium guaiacolsulfonate		78247-49-1	Price

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