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Arylquins Target Vimentin to Trigger Par-4 Secretion for Tumor Cell Apoptosis

Arylquins Target Vimentin to Trigger Par-4 Secretion for Tumor Cell Apoptosis

Ravshan Burikhanov, Vitaliy M Sviripa, Nikhil Hebbar, Wen Zhang, W John Layton, Adel Hamza, Chang-Guo Zhan, David S Watt, Chunming Liu, Vivek M Rangnekar

Nat Chem Biol. 2014 Nov;10(11):924-926.

PMID: 25218743

Abstract:

The tumor suppressor protein prostate apoptosis response-4 (Par-4), which is secreted by normal cells, selectively induces apoptosis in cancer cells. We identified a 3-arylquinoline derivative, designated Arylquin 1, as a potent Par-4 secretagogue in cell cultures and mice. Mechanistically, Arylquin 1 binds vimentin, displaces Par-4 from vimentin for secretion and triggers the efficient paracrine apoptosis of diverse cancer cells. Thus, targeting vimentin with Par-4 secretagogues efficiently induces paracrine apoptosis of tumor cells.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1630743735	Arylquin 1		1630743-73-5	Price

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